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The British introduced allopathy medicine in India. Initially, the Western medicine enclave only within the officers and military of British later makes it extend to Indian for several purposes, the only benefit of them in various facets. Here I am trying to reveal the history of the vaccine under the British Raj in Orissa. Oriya speaking people were segmented under the several presidencies viz, Madras, Bengal, and Nagpur administration that south, eastern, and Western Orissa, respectively. Orissa was one of fully clouded state of smallpox in the early colonial rule. Hence the British used a vaccine, especially against smallpox. But the indigenous people were not merely ready to take a vaccine against smallpox, even though the people died of it.