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Abstract

Cancer is accepted to be one of the prominent causes of mortality. Oral cancer involves abnormal, malignant tissue growth in the oral cavity (lip, tongue, gum, the base of the mouth, cheek, and palate). Carcinoma is also referred to as Oral squamous cell Carcinoma (OSCC), more than 95% of oral cancer is diagnosed as OSCC. This is considered as the sixth commonest cancer worldwide and third among all other cancers in India. It accounts for six percent of all cancers in Worldwide, greater than 300,000 new carcinoma cases are diagnosed annually. In India Oral cancer is the leading cancer type among men representing approximately 11.3% of all male cancers and in women, it is the fifth most prevalent cancer representing about 4.3% of all female cancers. Major causative factors for OSCC are smoking or chewing tobacco, excessive consumption of alcohol, viral or bacterial infections and hereditary factors (family history). Indian population includes 14% smoking tobacco users as well as 26% chewing tobacco users, which indicates that the use of chewing tobacco remains the greatest challenge for health professionals (Global Adult Tobacco Survey., 2009-10).Despite having advanced therapeutic options, like surgical excision (removal) of the tumor followed by chemo or radiation therapy, OSCC is characterized by poor prognosis and a low survival rate. 


 

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How to Cite
Runjhun Mathur, Meenakshi Jha, Sheo Prasad Shukla, Ravi Kant Singh, Gaurav Saini, Anju Shrivastava, Kush Kumar Nayak, & Abhimanyu Kumar Jha. (2020). Promoter Hypermethylation Of Tumor Suppressor Genes In Oral Squamous Cell Carcinoma (OSCC) And Their Possible Reactivation By The Use Of Natural Compounds. International Journal of Bio-Science and Bio-Technology, 12(3), 60-66. Retrieved from https://journals.eduindex.org/index.php/ijbsbt/article/view/19931