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In the Textile Industry the Functional textiles of any product varies with its Finishing nature. My idea of this project is to produce an Eco friendly antimicrobial finishing to bed spreads using cactus extract for mosquito repellence. Finishing improves the fabrics performance and give special Cactus Miller, Psidium guajava and Azadirachtaindica etc for the mosquito repellent is one of the most effective tools for protecting human from vector borne diseases. To impact the Eco friendly antimicrobial finishing to bed spreads using cactus extract for mosquito repellence, the method chosen is Dip-Dry method of Cactus Extract. This work is a small effort in developing an eco friendly mosquito repellent finished fabric using the cactus extract. The fabric was finished by padding mangle method and evaluated using a exito chamber test. After finishing, the finished fabric showed 100% of repellent activity for direct application method. This study helps in the development of a mosquito repellent fabric which protects the human beings from the mosquito bites and thereby promising safety from the mosquito borne diseases. The Aim of this Project is to serve the Society without mosquito and the diseases.