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It is known that the presence of intrahepatic cholestasis with a deficiency of bile acids in the intestine is complicated by impaired absorption, leading to a deficiency of fat-soluble vitamins (D, K), impairment of hemocoagulation and disorder of mineral metabolism. Existing therapeutic approaches in dental practice, aimed at correcting clinical and biochemical changes in cholestasis, require reflection, since there is a need to develop optimal treatment regimens, determined by both the nosological form and the severity of the disease. In the serum, it was determined the activity of aspartatamine transferase (AST), alkaline phosphatase (APh), gamma-glutamyl transpeptidase (GGTP), and bile acid content (BA) in the serum on a Mindray BA-88-A biochemical analyzer using reagents from HUMAN.

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