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Nowadays headache is very common. A Large number of people are being suffering from various types of day to day headaches. Migraine is one of the specific types of headache in which patients feel intense pain in one side of their head. Nausea, vomiting, sensitivity towards light or sound are also the major symptoms of migraine. It has been seen that migraine influences the health of patients very badly. The present research represents the psycho- physical impact of migraine in adults. The term psycho-physical refers the psychological and physical health. 100 adults “Mean age 35” in which 50 migraine patients and 50 healthy adults were selected from Jharkhand. At the very outset data was collected from diagnosed migraine patients afterwards from control group, which were healthy adults. World Health Organization Quality of Life (WHOQOl) scale was used to measure the psycho-physical impact, Migraine Disability Assessment Scale (MIDAS) was used to know the disability level of migraine and General Health Questionnaire-12 (GHQ-12) was used to identify healthy adults. Result reveals that migraine patients have significantly poorer psycho-physical health than healthy adults and severe migraine patients have significantly poorer psycho-physical health than mild migraine patients.