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Abstract
The current research procedure involved the evolvement of analytical method by UV spectrophotometry for precise, simple, accurate and rapid assessment of Atorvastatin calcium (solid dosage form) in marketed and bulk dosage form.This study involved checking the solubility of drug in methanol.The drug showedgood solubility in solvent, sothestock solution was prepared in methanol. This drug showed good absorbance at wavelength 250 nm. Five different concentrations were prepared from 2-10 μg/ml and Beer’s law was obeyed by them. For the standard stock solution, correlation coefficient was 0.996. Level of percentage recovery was estimated at 80%, 100% and 120% and it was found to be 99.64%.No interference of any foreign particle or excipients was observed throughout the assessment of drug in the formulation. Moreover, this method of validation was found to be inexpensive and chemicals required during the entire procedurewere arranged easily.The validation of result of analysis was done as per ICH guidelines and it wasobserved that for the purpose of routine laboratory analysis and quality control check of pharmaceutical formulations, the proposed method can be utilised.