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Abstract
Rhizosphere soil of medicinal plants has been explored for many years in the search of novel microorganisms. These microorganisms were rich in many important bioactive molecules having impotence in new drug discovery. Actinomycetes a class of microorganisms showed maximum potential for antibiotic production in the past few decades. We selected the rhizospheres soil of a medical plant Berberis aeristata (Daru haldi) known for its use in Ayurveda medicine. One hundred forty actinomycetes cultures were isolated from the rhizosphere soil of the medical plant and identified using biochemical tests. These isolates were grown in different media under a set of optimum growth conditions. Four of these actinomycetes isolates (A1 & A2, A17, and A20) shown anti-bacterial activity against important human pathogens including E. coli and Pseudomonas spps.